Kate (Hayden Panettiere), an alpha wolf, lives her life responsibly, focusing on duty and discipline. Humphrey (Justin Long), an omega, lives for fun and friends. Humphrey has a crush on Kate, but in their pack he doesn't stand a chance. One night, they are captured by humans and taken from their home, Jasper Park, Canada, to a reserve in Idaho  to repopulate the species in the United States. As their pack flounders without its leader, Kate and Humphrey set out on an adventure to get back to their home range.